Richard Carliss, Ph.D.
Phone: (540) 985-9961
Courses taught: Genetics, Molecular Biology, Cell Biology and Anatomy and Physiology.
Research program at JCHS:
1) Cellular aging and lifestyle. We are currently assessing the degree to which aging and general health status may be correlated to telomeric shortening. Telomeres are a repeating series of base sequences that act to protect chromosomes from degradation as cells divide.
2) Pseudomonas aeruginosa is studied to determine the extent to which regulation of rahU, a protein newly-discovered in our laboratories, may play a central role in the infection of lung in cystic fibrosis patients.
Positions/Employment, Memberships and Honors:
Graduate Ph.D., Northwestern University Dept. Neurobiology and Physiology, 1983-1989
Postdoc, Dept. Neurobiology and Anatomy, University Rochester, 1989-1991
Senior Scientist, Schering-Plough Research Institute, 1991 -1992.
Principal Scientist, Schering-Plough Research Institute, 1992 -2000.
Director Pharmacology/Toxicology, Algos Pharmaceuticals, Inc., 2000-2001
Director Pharmacology/Toxicology, Endo Pharmaceuticals, Inc., 2001-2004
Assistant Professor, Dept. Clinical Laboratory Sciences, USA, 2004-2008
Chief Scientific Officer, Trinity Laboratories, Inc. 2007 - 2011.
Scientific Organization Memberships:
American Pain Society
Society for Neuroscience
Magnum Cum Laude
Publications (recent/paritial list):
Nemmani KV, Grisel JE, Stowe JR, Smith-Carliss R, Mogil JS. Modulation of morphine analgesia by site-specific N-methyl-D-aspartate receptor antagonists: dependence on sex, site of antagonism, morphine dose, and time. Pain 2004 Jun;109(3):274-83.
Grisel, JE, Allen S, Nemmani KVS, Fee JR and Smith-Carliss, R. Dextromethorphan potentiation of morphine analgesia in mice is sex-specific. Physiology, Biochemistry and Behavior 2005 May;81(1):131-8.
Carliss RD, Radovsky A, Chengelis CP, O'Neill TP, Shuey DL. Oral administration of dextromethorphan does not produce neuronal vacuolation in the rat brain. Neurotoxicology. 2007 Jul;28(4):813-8
Whitney L. Hough, Marcin Smiglak, Richard P. Swatloski, Scott K. Spear, Daniel T. Daly, Juliusz Pernak, Judith E. Grisel, Richard D. Carliss*, James H. Davis*, Jr., and Robin D. Rogers*. The Third Evolution of Ionic Liquids: Active pharmaceutical Ingredients as Exemplified by Ranitidine Docusate and Lidocaine Docusate. New J. Chem., 2007, 31, 1429 - 1436. (NJC first author status indicated by *)